✦ LIBER ✦

Trichloroethylene and dichloroethylene: A critical review of teratogenicity

✍ Scribed by Bryan D. Hardin; Bruce J. Kelman; Robert L. Brent

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 189 KB
Volume: 73
Category: Article
ISSN: 1542-0752
DOI: 10.1002/bdra.20192

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✦ Synopsis

Abstract

Trichloroethylene (TCE) and dichloroethylene (DCE) are high‐volume industrial chemicals frequently found as contaminants in public drinking water supplies. The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE are specific cardiac teratogens and that drinking water contaminated with them increases the risk of congenital heart defects in exposed human populations. In contrast, other laboratory and epidemiologic studies do not find an increase in developmental effects, either in general or specifically affecting the heart. This laboratory and epidemiologic base was reviewed to evaluate the strengths and weaknesses of the conflicting published reports. We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.

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