Trichilin B, a novel limonoid with highly rearranged ring system from Trichilia connaroides

✍ Scribed by Zhao-Liang Geng; Xin Fang; Ying-Tong Di; Qiang Zhang; Ying Zeng; Yue-Mao Shen; Xiao-Jiang Hao

• Book ID: 104096343
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 400 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.147

✦ Synopsis

Trichilin B (2), a limonoid having an unprecedented highly rearranged ring system, along with biosynthetically correlated trichilin A (1), was isolated from Trichilia connaroides. The structures were elucidated by spectroscopic analysis. Compound 2 features a unique 9,17-oxygen bridge, while two unprecedented d-lactone rings fused to rings A and B at C-5, C-9 and ring C at C-8, C-14. Their cytotoxic activities were also evaluated.