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Tricarboxylic Acid Cycle Activity Measured by13C Magnetic Resonance Spectroscopy in Rats Subjected to the Kaolin Model of Obstructed Hydrocephalus

✍ Scribed by Torun M. Melø; Asta K. Håberg; Øystein Risa; Daniel Kondziella; Pierre-Gilles Henry; Ursula Sonnewald

Publisher
Springer
Year
2011
Tongue
English
Weight
303 KB
Volume
36
Category
Article
ISSN
0364-3190

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## Abstract Measurement by ^13^C magnetic resonance spectroscopy (MRS) of the incorporation of label from [1‐^13^C] glucose, initially into C4 of glutamate, allows the regional tricarboxylic acid (TCA) cycle flux (F~TCA~) to be determined in the human brain. In this study, a direct ^13^C MRS approa