Tributylphosphine-catalyzed Stetter reaction of N,N-dimethylacrylamide: synthesis of N,N-dimethyl-3-aroylpropionamides

✍ Scribed by Ji Hyeon Gong; Yang Jin Im; Ka Young Lee; Jae Nyoung Kim

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 78 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02344-9

✦ Synopsis

The reaction of arylaldehydes 1 and N,N-dimethylacrylamide in the presence of tributylphosphine afforded N,Ndimethyl-3-aroylpropionamides 2 in moderate yields. The reaction might involve the formation of a-oxo ylide A.