Tributylmagnesium Ate Complex-Mediated Bromine—Magnesium Exchange of Bromoquinolines: A Convenient Access to Functionalized Quinolines.

Tributylmagnesium ate complex-mediated b

Tributylmagnesium ate complex-mediated bromine–magnesium exchange of bromoquinolines: a convenient access to functionalized quinolines

✍ Sylvain Dumouchel; Florence Mongin; François Trécourt; Guy Quéguiner 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 164 KB

2-, 3-and 4-bromoquinolines were converted to the corresponding lithium tri(quinolyl)magnesates at -10°C by treatment with Bu 3 MgLi in THF or toluene. The resulting organomagnesium derivatives were quenched by various electrophiles to afford functionalized quinolines.