Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

✍ Scribed by Anees A. Siddiqui; Ravinesh Mishra; Mohammad Shaharyar; Asif Husain; Mohd. Rashid; Palash Pal

• Book ID: 104005212
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 205 KB
• Volume: 21
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.12.028

✦ Synopsis

A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol.