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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists

✍ Scribed by Chi B. Vu; Pamela Shields; Bo Peng; Gnanasambandam Kumaravel; Xiaowei Jin; Deepali Phadke; Joy Wang; Thomas Engber; Eman Ayyub; Russell C. Petter


Book ID
108073425
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
266 KB
Volume
14
Category
Article
ISSN
0960-894X

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A series of novel and known 5-substituted 7-amino-2-(2-furyl) [1,2,4]triazolo [1,5a][1,3,5]triazine derivatives were synthesized and tested for adenosine receptor antagonism in radioligand binding assays at all four adenosine receptor subtypes and for inhibition of the agonist-induced cyclic AMP res