## Background To expand access to allogeneic haematopoietic stem cell transplantation (allo-HSCT) to patients who are ineligible for conventional myeloablative FTBI-or busulfan-based preparative regimens, the idea of reduced intensity conditioning (RIC) in the early 1990s, and somewhat later in th
โฆ LIBER โฆ
Treosulfan-based conditioning regimen for allogeneic haematopoietic stem cell transplantation in patients with thalassaemia major
โ Scribed by Maria Ester Bernardo; Marco Zecca; Eugenia Piras; Adriana Vacca; Giovanna Giorgiani; Chiara Cugno; Giovanni Caocci; Patrizia Comoli; Angela Mastronuzzi; Pietro Merli; Giorgio La Nasa; Franco Locatelli
- Book ID
- 108675997
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 103 KB
- Volume
- 143
- Category
- Article
- ISSN
- 0007-1048
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## Abstract To circumvent the cardiac toxicity of highโdose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VPโ16) (40 mg/kg