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TREK Channel Pore Probed by Cysteine Scanning Mutagenesis and Structural Modelling

✍ Scribed by Piechotta, Paula L.; Stansfeld, Phill J.; Bollepalli, Murali K.; Rapedius, Markus; Andres-Enguix, Isabelle; Shang, Lijun; Fritzenschaft, Hariolf; Sansom, Mark S.P.; Tucker, Stephen; Baukrowitz, Thomas


Book ID
122219189
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
41 KB
Volume
98
Category
Article
ISSN
0006-3495

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Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (T) bound to thrombomodulin (TM), a membrane receptor present on the surface of endothelial cells. The understanding of this complex biological system is in part limited due to the lack of integration