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Treg Potency Assay: Suppression of T Cell Cytokine Expression in Response to T Cell Specific Antigenic Stimulation of Autologous PBMC

โœ Scribed by Smita Ghanekar; Joyce Ruitenberg


Book ID
113539995
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
43 KB
Volume
123
Category
Article
ISSN
1090-2341

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## Abstract Naturally occurring CD4^+^ regulatory Tโ€„cells can be identified on the basis of expression of CD25 and suppression of Tโ€„cell responses __in vitro__ after TCR triggering. Here, we demonstrate that a CD134^+^ subset of CD4^+^CD25^+^ Tโ€„cells in naive rats suppresses antigenโ€specific Tโ€„cell