Treatment with vancomycin may offer a novel approach to arthritis and other autoimmune disorders,

Low prevalence of antibodies to glucose-

Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders

✍ Isao Matsumoto; David M. Lee; Raphaela Goldbach-Mansky; Takayuki Sumida; Carol A 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB 👁 2 views

## Abstract ## Objective Arthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients.