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Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats

✍ Scribed by Melanie E. Inkster; Mary A. Cotter; Norman E. Cameron

Book ID: 113586688
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 406 KB
Volume: 561
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2006.12.029

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Background Continuous hyperglycemia is implicated in the pathogenesis of chronic diabetic complications. It is not well known, however, how and to what extent the development of neuropathy is inhibited by blood glucose control in subjects with Type 2 diabetes. We investigated therefore the effects o