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Treatment with low-dose oral etoposide in patients with myelodysplastic syndromes

✍ Scribed by Donald C. Doll; Lawrence M. Kasper; Raymond Taetle; Alan F. List


Book ID
114119167
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
560 KB
Volume
22
Category
Article
ISSN
0145-2126

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Treatment of myelodysplastic syndromes w
✍ Spitzer, Thomas R. ;Lazarus, Hillard M. ;Crum, Edward D. ;Weisman, Russell πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 374 KB

Several cytotoxic agents when used in vitro in very low concentrations have been shown to induce differentiation of leukemic cells. We treated 18 patients with rnyelodysplastic syndromes with lowdose oral 6-thioguanine (6-TG; 20 to 60 rng daily). Four patients demonstrated significant improvement in