Treatment of myelodysplastic syndromes w
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Spitzer, Thomas R. ;Lazarus, Hillard M. ;Crum, Edward D. ;Weisman, Russell
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Article
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1988
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John Wiley and Sons
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English
β 374 KB
Several cytotoxic agents when used in vitro in very low concentrations have been shown to induce differentiation of leukemic cells. We treated 18 patients with rnyelodysplastic syndromes with lowdose oral 6-thioguanine (6-TG; 20 to 60 rng daily). Four patients demonstrated significant improvement in