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Treatment with imatinib results in reduced IL-4-producing T cells, but increased CD4+ T cells in the broncho-alveolar lavage of patients with systemic sclerosis

✍ Scribed by Anagha A. Divekar; Dinesh Khanna; Fereidoun Abtin; Paul Maranian; Rajeev Saggar; Rajan Saggar; Daniel E. Furst; Ram Raj Singh

Book ID: 113542024
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 975 KB
Volume: 141
Category: Article
ISSN: 1090-2341
DOI: 10.1016/j.clim.2011.08.010

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## Abstract ## Objective Although gastrointestinal tract dysfunction is a common feature in patients with systemic sclerosis (SSc; scleroderma), few studies have addressed the pathogenetic mechanisms of gastrointestinal tract involvement in SSc. We previously showed that severe fibrosis and increa