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Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson–Gilford progeria syndrome mutation

✍ Scribed by Shao H. Yang; Xin Qiao; Loren G. Fong; Stephen G. Young

Book ID
116273262
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
270 KB
Volume
1781
Category
Article
ISSN
1388-1981

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Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder normally caused by a spontaneous heterozygous mutation in the LMNA gene that codes for the nuclear lamina protein lamin A. Several enzymes are involved in the processing of its precursor, prelamin A, to the mature lamin A