A multicenter evaluation of intensified,
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Francis Lรฉvi; Rachid Zidani; Silvano Brienza; Luigi Dogliotti; Bruno Perpoint; M
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Article
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1999
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John Wiley and Sons
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English
โ 140 KB
๐ 2 views
## BACKGROUND. The combination of 5-fluorouracil (5-FU), leucovorin (LV), and oxaliplatin (l-OHP) was shown to be both more active against metastatic colorectal carcinoma and better tolerated if the drug delivery rate was chronomodulated according to circadian rhythms rather than constant. This all