Treatment outcome and dose-response relationship in infants younger than 1 year treated for retinoblastoma with primary irradiation

✍ Scribed by Fontanesi, James; Pratt, Charles B.; Kun, Larry E.; Hustu, H. Omar; Coffey, Douglas; Meyer, David

• Book ID: 102647311
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 591 KB
• Volume: 26
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199605)26:5<297::aid-mpo1>3.0.co;2-d

✦ Synopsis

Thirty-three infants (I80 cGy (n = 10). One child died of metastatic disease at 42 months. Three patients have developed second malignant neoplasms; two have succumbed at 88 and 125 months post-RB diagnosis; the remaining patients are alive at 6-259 mozths postdiagnosis (median followup = 127 months). Local control with irradi-ation alone and supplemented cryotherapy given within 2 months (n = 2) was maintained in 29 eyes, with no statistical difference seen for total doses C36 Gy (21/28 eyes) vs. >36 Cy (8/16). Of 15 eyes that required salvage therapy, tumor control has been maintained in 13. Enucleation was requried for four patients, two with recurrent retinoblastoma and one with a massive retinal hemorrhage, one with a phthisical eye. Cataract formation was documented in 23 eyes (87.5%) treated with anterior field. Three patient treated with lens-sparing techniques developed cataract. At last follow-up, 23 of 30 patients tested (77%) had visual acuity of 20/100 or better. This experience confirms early observations in that doses a 3 6 Gy do not appear to improve local control with ir- radiation alone in infants (<365 days) with retinoblastoma. o 1996 Wiley-Liss, Inc.