Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
Treatment of the blastic phase of chronic myelogenous leukemia with mitoxantrone and high-dose cytosine arabinoside
β Scribed by Hagop M. Kantarjian; Ronald S. Walters; Michael J. Keating; Moshe Talpaz; Borje Andersson; Miloslav Beran; Kenneth B. McCredie; Emil J Freireich
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 511 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0008-543X
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## BACKGROUND. Cytarabine is an essential drug for inducing remission of acute myelogenous leukemia, and it is also one the most effective drugs used as salvage therapy for patients with all types of relapsed acute leukemia. Nevertheless, there is considerable room for improvement in the treatment
Department of Heremission whereas 5 patients (23%) succumbed to early death and 3 patients (14%) matology and Oncology, Go Β¨ttingen, Germany. did not respond. Blood counts recovered at a median of 33.5 days after the start 2 Westfa Β¨lische Wilhelms University, Department of treatment and complete r