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Treatment of sulfur mustard (HD)-induced lung injury

✍ Scribed by Dana R. Anderson; Susan L. Byers; Keith R. Vesely

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
95 KB
Volume
20
Category
Article
ISSN
0260-437X

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Attenuation of half sulfur mustard gas-i
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Airway instillation into rats of 2-chloroethyl ethyl sulfide (CEES), the half molecule of sulfur mustard compound, results in acute lung injury, as measured by the leak of plasma albumin into the lung. Morphologically, early changes in the lung include alveolar hemorrhage and fibrin deposition and t

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## Abstract The purpose of this study was to develop antioxidant liposomes as an antidote for mustard gas–induced lung injury in a guinea pig model. Five liposomes (LIP‐1, LIP‐2, LIP‐3, LIP‐4, and LIP‐5) were tested with differing levels of phospholipid, cholesterol, phosphatidic acid, tocopherol (

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The chemical warfare agent analog, 2-chloroethyl ethyl sulfide, known as 'half-mustard gas' (HMG), is less toxic and less of an environmental hazard than the full molecule and has been shown to produce an acute lung injury in rats when instilled via intrapulmonary injection. This injury is character