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Treatment of spinal epidural neuroblastoma xenografts in rats using anti-GD2 monoclonal antibody 3F8

✍ Scribed by Ira Bergman; Ehud Arbit; Marc Rosenblum; Steven M. Larson; Glenn Heller; Nai -Kong V. Cheung

Publisher: Springer US
Year: 1993
Tongue: English
Weight: 963 KB
Volume: 15
Category: Article
ISSN: 0167-594X
DOI: 10.1007/bf01050069

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## Abstract ## BACKGROUND Antigen ganglioside GD2 is expressed abundantly on neuroblastoma (NB) cells. Anti‐GD2 monoclonal antibody (MoAb) 3F8 kills NB cells by complement‐dependent cytotoxicity and antibody‐dependent cellular cytotoxicity. Its utility in bone marrow (BM) purging is evaluated by a