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Treatment of spinal epidural neuroblastoma xenografts in rats using anti-GD2 monoclonal antibody 3F8

✍ Scribed by Ira Bergman; Ehud Arbit; Marc Rosenblum; Steven M. Larson; Glenn Heller; Nai -Kong V. Cheung


Publisher
Springer US
Year
1993
Tongue
English
Weight
963 KB
Volume
15
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND Antigen ganglioside GD2 is expressed abundantly on neuroblastoma (NB) cells. Anti‐GD2 monoclonal antibody (MoAb) 3F8 kills NB cells by complement‐dependent cytotoxicity and antibody‐dependent cellular cytotoxicity. Its utility in bone marrow (BM) purging is evaluated by a