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Treatment of Smith-Lemli-Opitz syndrome: Results of a multicenter trial

✍ Scribed by Irons, Mira; Elias, Ellen R.; Abuelo, Diane; Bull, Marilyn J.; Greene, Carol L.; Johnson, Virginia P.; Keppen, Laura; Schanen, Carolyn; Tint, G. Stephen; Salen, Gerald

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
169 KB
Volume
68
Category
Article
ISSN
0148-7299

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✦ Synopsis

Patients with the RSH or Smith-Lemli-Opitz syndrome (SLOS) have an inborn error of cholesterol biosynthesis which results in a deficiency of cholesterol and an elevation of the cholesterol precursor, 7-dehydrocholesterol. A treatment protocol consisting of administration of cholesterol ؎ bile acids was initiated in an attempt to correct the biochemical abnormalities seen. Fourteen patients (8 female, 6 male: ages 2 months to 15 years) have now been treated for 6-15 months. Three patients received cholesterol alone, while 11 patients received cholesterol and one or more bile acids. Biochemical improvement in sterol levels and in the ratio of cholesterol to total sterols was noted in all patients. The most marked improvement was noted in patients presenting with initial cholesterol levels <40 mg/dl. No toxicity was observed. Clinical improvement in growth and neurodevelopmental status was also observed.

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