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Treatment of seven cases of chronic granulomatous disease with sulfamethoxazole-trimethoprim (SMX-TMP)

✍ Scribed by Yohnosuke Kobayashi; Daisuke Amano; Kazuhiro Ueda; Yuji Kagosaki; Tomofusa Usui

Publisher: Springer
Year: 1978
Tongue: English
Weight: 441 KB
Volume: 127
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00493540

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✦ Synopsis

Seven male Japanese children with chronic granulomatous disease were given sulfamethoxazole-trimethoprim (SMX-TMP) for recurrent pyogenic infections, most of which had proved difficult to control with other antibiotics. With continous treatment the children remained free of infections severe enough to necessitate hospitalization, except on one occasion. Serious complications, including hematological disorders, never occurred during therapy and there were no changes in leukocyte function during therapy. These results indicate that SMX-TMP should be considered in the treatment of bacterial infections associated with chronic granulomatous disease.

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