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Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications

✍ Scribed by O'Dell, James R.; Haire, Claire E.; Erikson, Nils; Drymalski, Walter; Palmer, William; Eckhoff, P. James; Garwood, Vernon; Maloley, Pierre; Klassen, Lynell W.; Wees, Steven


Book ID
115459662
Publisher
Massachusetts Medical Society
Year
1996
Tongue
English
Weight
107 KB
Volume
334
Category
Article
ISSN
0096-6762

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## Abstract ## Objective To investigate whether interactions of sulfasalazine (SSZ) with reduced folate carrier (RFC), the dominant cell membrane transporter for natural folates and methotrexate (MTX), may limit the efficacy of combination therapy with MTX and SSZ in patients with rheumatoid arthr