Treatment of renal calcium stone disease with the synthetic glycosaminoglycan pentosan polysulphate
✍ Scribed by B. Fellström; U. Backman; B. Danielson; B. Wikström
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 255 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0724-4983
No coin nor oath required. For personal study only.
✦ Synopsis
Glycosaminoglycans (GAGs)
are potent inhibitors of calcium oxalate growth and aggregation. The synthetic G A G pentosan polysulphate (PPS) was used in the treatment of patients with renal calcium stone disease. Altogether, 121 patients were included in an open trial over a 3-year-period. The average stone episode rate and the stone operation rate were no different during treatment and in the pretreatment period. Altogether 48% of the patients were entirely stone-free during follow-up, whereas 29/56 patients who continued to form stones reported smaller stones that were more easily passed. It is concluded that there may be a role for PPS in the treatment of recurrent renal calcium stone disease, but a controlled study may be needed.