Treatment of refractory and relapsed non-Hodgkin's lymphoma with ifosfamide, methotrexate and etoposide
β Scribed by Graeme Sangster; W. Nigel Patton; Richard I. Harris; Robert J. Grieve; Michael J. Leyland
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 336 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Fifty-five patients, initially diagnosed as having advanced high grade non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD) refractory to first-line treatment or in relapse, were treated with ifosfamide 6 g/m', infused over 48 h, followed by mitoxantrone 12 mg/m2. The regimen repeated at three-wee
We assessed the efficacy of an etoposide, ifosfamide and methotrexate combination therapy (VIM) in 24 patients failing the LNH 84 protocol. Eight of these patients were refractory to the LNH 84 induction regimen, 10 were partial responders and the six remaining attained complete response after LNH 8
## BACKGROUND. Cladribine (2-chlorodeoxyadenosine) is a purine nucleoside analog with cytotoxic activity against both resting and proliferating cells. Clinical studies with cladribine have reported antitumor activity against various hematologic malignancies.
## Abstract A phaseβII study was conducted by the Cancer and Leukemia Group B (CALGB) in patients with refractory and relapsed nonβHodgkin's lymphoma (NHL) to assess the activity of the combination of etoposide and cisplatin. Sixtyβfive patients were entered on study, and 51 patients were evaluated