Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation

✍ Scribed by M. Maitland DeLand; Robert A. Weiss; David H. McDaniel; Roy G. Geronemus

• Book ID: 102468917
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 147 KB
• Volume: 39
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.20455

✦ Synopsis

Abstract

Background and Objective

Light‐emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation‐induced dermatitis in breast cancer.

Materials and Methods

Patients (n = 19) were treated with LED photomodulation (Gentlewaves™, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity‐modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age‐matched controls (n = 28) received IMRT without LED photomodulation.

Results

In LED‐treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED‐treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment.

Conclusion

LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy. Lasers Surg. Med. 39:164–168, 2007. © 2007 Wiley‐Liss, Inc.