Treatment of pure red-cell aplasia following major ABO-mismatched T-cell-depleted bone marrow transplantation

✍ Scribed by R. Or; E. Naparstek; N. Mani; S. Slavin

• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 442 KB
• Volume: 4
• Category: Article
• ISSN: 0934-0874
• DOI: 10.1007/bf00336406

✦ Synopsis

Major ABO-mismatched bone marrow transplantation (BMT) may be accompanied by red-cell haemolysis, but pure red-cell aplasia following BMT is a rare complication. Two cases of transient pure red-cell aplasia following T-lymphocyte-depleted BMT for a period of greater than 20 weeks are described, both of which responded to one cycle of plasmapheresis. The prompt response of the two patients described with red-cell aplasia with no evidence of haemolysis suggests that plasmapheresis may be considered in such clinical situations as a first treatment of choice before attempting more complex modes of therapy.