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Treatment of Philadelphia-positive acute lymphocytic leukemia with tyrosine kinase inhibitors: What is the optimal regimen?

โœ Scribed by Amber Fullmer; Elias Jabbour


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
70 KB
Volume
85
Category
Article
ISSN
0361-8609

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The molecular basis of the Philadelphia chromosome (Ph') is a structurally altered c-abl (bcr-abl) gene which encodes an abnormally large protein with protein tyrosine kinase activity. Herbimycin A, which effectively reduced intracellular phosphorylation by bcr-abl tyrosine kinase, preferentially in