Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia with imatinib in combination with chemotherapy
β Scribed by Ryuzo Ohno; the Japan Adult Leukemia Study Group
- Book ID
- 107540341
- Publisher
- Current Science Inc.
- Year
- 2006
- Tongue
- English
- Weight
- 297 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1558-8211
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## Abstract ## BACKGROUND Elderly patients with Philadelphia chromosomeβpositive acute lymphoblastic leukemia (Ph+ALL) have a poor prognosis, with a low complete remission (CR) rate, high induction mortality, and short remission duration. Imatinib (IM) has a favorable toxicity profile but limited
Transient pancytopenia preceding acute lymphoblastic leukemia (pre-ALL) is a rare but well-known occurrence usually affecting children and adolescents. Though pre-ALL in a few adults has ever been reported, the association of this preleukemic syndrome with positive Philadelphia chromosome and P190(B