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Treatment of periodic limb movements in sleep with selegiline HCl

✍ Scribed by Manavdeep Grewal; Raed Hawa; Colin Shapiro

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 33 KB
Volume: 17
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10082

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✦ Synopsis

Abstract

Thirty‐one patients undergoing treatment with selegiline HCl for periodic limb movements in sleep (PLMS) were examined with respect to specific sleep composition in a retrospective study. Pre‐ and post‐treatment overnight polysomnographs revealed a highly significant decrease in the number of PLMS per hour of total sleep time (P < 0.0005). The alerting effect associated with selegiline was not found to have significant effect on patients' sleep efficiency or sleep‐onset latency (P > 0.10). As controversy continues regarding the medicated treatment of PLMS, our findings with selegiline point to an alternative for clinicians to consider. © 2002 Movement Disorder Society

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