Treatment of Pasteurella pestis infection in mice

• Book ID: 104133489
• Publisher: Elsevier Science
• Year: 1943
• Tongue: English
• Weight: 204 KB
• Volume: 235
• Category: Article
• ISSN: 0016-0032
• DOI: 10.1016/s0016-0032(43)90866-x

✦ Synopsis

considered it of interest to test some of the sulfonamide drugs against a strain of Pasteurella pestis isolated in the United States. Many of the newersulfonamide drugshave not as yet been triedagainst plague infection and we have therefore tested sulfathiazole (Merck and Co., Rahway, N. J.), sulfadiazine (Lederle Laboratories, New York), and succinyl sulfathiazole (Sharpe and Dohme, Philadelphia).

Reports of the trial of some sulfonamide drugs in experimental and clinical plague infection have been published in other countries. Schfitze (Lancet, I: 266, 1939) has reported on the use of M. and B. 693 (sulfapyridine), soluseptasine and diaminodiphenylsulfone glucoside against the infection in rats and mice. M. and B. 693 was the most efficacious of the threedrugs in both rats and mice, soluseptasine protected rats but not mice, and the sulfone protected mice but not rats. Antiplague serum produced results comparable to the results obtained with M. and B. 693. Sokhey and Dikshit (Lancet, I: lO4O, I94o) found sulfathiazole superior to sulfapyridine and as effective as a good antiplague serum. Durand