Treatment of oat-cell carcinoma of the lung in the community

✍ Scribed by Citronbaum, Ronald

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 199 KB
• Volume: 4
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950040413

✦ Synopsis

Abstract

Nine patients with “limited” (thoracic) small‐cell lung carcinoma were treated with combined chemotherapy and radiotherapy (involved field and prophylactic whole brain). Induction drugs were Vincristine, Adriamycin, and Cyclophosphamide; and Cyclophosphamide, Vincristine, and CCNU for maintenance. Eight out of nine patients (89%) continue NED at a median follow‐up time of 12 months. This group is compared to 21 patients with more extensive disease and 6 patients with limited disease using various other regimens. Median survival in the extensive group was 5 months and 8 months for the limited‐diseased group treated with single agents. Intensive combination chemo‐irradiation therapy is safe and highly effective in patients with limited oat‐cell carcinoma of the lung, and leads to prolonged disease‐free survival.