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Treatment of neuroblastoma in mice with bromoacetylcholine and bromoacetate

✍ Scribed by Chung Y. Chiou

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
524 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

Bromoacetylcholine (30 mg/kg intratumor one to three times per day) and bromoacetate (12 mg/kg intratumor two times per day) inhibited neuroblastoma in A/J mice efficiently and prolonged the lifespan of these animals at least 200%. Since the neuroblastoma-inoculated A/J mice are considered to be comparable to human neuroblastoma, the cytolytic action of bromoacetylcholine and bromoacetate on murine neuroblastoma warrants further studies on patients. The fact that these tumors were cured in adult mice is very important because older children and adults with neuroblastoma have the poorest prognosis.

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