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Treatment of metastatic malignant melanoma with 24 hours continuous venous infusion of dacarbazine and cisplatin

✍ Scribed by Fikri Icli; Handan Karaoguz; Dilek Dincol; Nazan Gunel; Ahmet Demirkazik

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 261 KB
Volume: 48
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930480312

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty consecutive patients with metastatic malignant melanoma were treated with a combination of 24 hours continuous infusion of dacarbazine (250 mg/m2) and cisplatin (20 mg/m2) for 5 days every 3 weeks. One patient (5%) achieved a complete response (CR) and 3 patients (15%) obtained a partial response (PR) with an overall response rate of 20%. Minimal response was observed in 5 other patients (25%). Complete response duration was 8 months. Median response duration of partial responders was 7 months. Median survival of all responders (CR+PR) was 8.5 months. Toxicity was mild to moderate.

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