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Treatment of metastatic and recurrent cervix cancer with chemotherapy: A randomised trial comparing hydroxyurea with cisdiamminedichloro-platinum plus methotrexate

✍ Scribed by Bezwoda, W. R. ;Nissenbaum, M. ;Derman, D. P.

Book ID: 102523534
Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 240 KB
Volume: 14
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950140105

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✦ Synopsis

In a randomised trial comparing singleagent chemotherapy (hydroxyurea) to combination chemotherapy in advanced cervix cancer, response was seen in 57% (including 13% CR) of patients receiving the combination (DDP + MTX) regimen. Responding patients survived significantly longer (11 months) than either those receiving hydroxyurea or those not responding to combination chemotherapy (4 months). Two patients remain in complete remission for 14+ and 17+ months.

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