Treatment of malignant scala posterior brain tumors in children: The chemotherapy of relapsed medulloblastoma with a dibromdulcitol containing drug regime and pharmacokinetic studies of dibromdulcitol in children
✍ Scribed by Schuler, Dezsõ ;Somló, Pál ;Koós, Rozólia ;Kálmánchey, Rozália ;Paraicz, Ervin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 262 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Abstract
Dibromdulcitol (Elobromol) has favorable pharmacokinetic parameters for the treatment of brain tumors: high spinal fluid/plasma ratio and long half‐life in spinal fluid. Oral application makes its administration easy. The drug combination vincristine, procarbazine, and dibromdulcitol proved to be effective in a pilot trial on relapsed medulloblastomas: 8 complete and 4 partial remissions were achieved from 16 cases. The main side effect was granulocytopenia, which was in some cases severe. However, in the doseschedule we used it did not delay the treatment longer than 1 week. © 1992 Wiley‐Liss, Inc.