Treatment of malignant gliomas with surgery, intraarterial chemotherapy with ACNU and radiation therapy

✍ Scribed by Felipe Vega; Luis Davila; Gilles Chatellier; Jacques Chiras; François Fauchon; Philippe Cornu; Laurent Capelle; Michel Poisson; Jean Yves Delattre

• Publisher: Springer US
• Year: 1992
• Tongue: English
• Weight: 373 KB
• Volume: 13
• Category: Article
• ISSN: 0167-594X
• DOI: 10.1007/bf00172762

✦ Synopsis

Fourty patients with malignant supratentorial gliomas received iterative intraarterial (IA) infusions of ACNU, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea at a dose of 150 mg repeated every 6 weeks. Group A consisted of eighteen patients previously treated with surgery, radiation therapy (RT) and sometimes chemotherapy, who received 1A ACNU at tumor recurrence. Group B consisted of twenty two patients who received IA ACNU in the postoperative pre-RT period. In group A, 8/18 patients (44%) had an objective response, including 6/12 anaplastic astrocytomas (AA) and 2/6 glioblastoma multiforme (GBM), while 10/18 patients (56%) did not respond. Median survival time was 6 months for GBM and 12 months for AA.

In group B, 6/22 patients (27%) had an objective response (4/18 GBM and 2/4 AA) and 16/22 patients (73%) did not respond. Nine patients had such an extensive tumor after one or two courses ofIA ACNU that RT was cancelled. Median survival time was 8 months for GBM and 8 months for AA.

Three patients (8%) had ophthalmologic toxicity on the infused side. There was no case of leukoencephalopathy.