Treatment of lymphosarcoma in the dog with L-asparaginase
✍ Scribed by Lloyd J. Old; Edward A. Boyse; H. A. Campbell; Robert S. Brodey; J. Fidler; Joseph D. Teller
- Publisher
- John Wiley and Sons
- Year
- 1967
- Tongue
- English
- Weight
- 449 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Eleven patients with acute lymphocytic leukemia in relapse were treated with L‐asparaginase and cytosine arabinoside (1‐β‐D‐arabinofuranosylcytosine) in induction therapy and the same drugs plus cyclophosphamide in maintenance therapy. Three patients had complete remissions lasting 6, 1
One hundred and fourteen patients with acute leukemia, 57 children (10 AML and 47 ALL) and 57 adults (37 AML and 20 ALL) were treated with L-asparaginase (Asnase) 200 or 1000 IU/kg daily for 30 days unless withdrawn on account of side effects. Combinations with other cytotoxic drugs were used in all
Courses of cytosine arabinoside followed by L-asparaginase were administered for 4 days each to 17 children with previously treated acute lymphatic leukemia, at 14to 27-day intervals. Complete or partial remission occurred in 81% of patients after the third or fourth course of therapy. Rlaintenance