Treatment of insulin lipoatrophy with monocomponent insulin

✍ Scribed by A. Teuscher

• Book ID: 104769400
• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 836 KB
• Volume: 10
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00423037

✦ Synopsis

A female diabetic with severe insulininduced lipoatrophy was successfully treated with a monoeomponent (MC) Lente preparation. This patient was studied for over 6 years and, during periods of treatment with various insulins of different purity, a variety of reactions was observed in the adipose tissue. Evidence is presented that lipoatrophy may be caused by insulin impurities. Lipoatrophy occurring after treatmens with recrystallized, mixed species Lente insulin was substantially reduced after treatment with 10 times recrystallized porcine Lente, but recurred on 4 times recrystallized beef Lente, Mso in areas where beef Lente was not injected. Beef insulin impurities seem more prone to produce lipoatrophy than pork insulin impurities. It is suggested that MC-insulin is the treatment of choice for this condition.