Treatment of hepatitis B virus-associated membranous nephropathy with adenine arabinoside and thymic extract
β Scribed by Lin, Ching-Yuang; Lo, Szecheng
- Book ID
- 109881932
- Publisher
- Nature Publishing Group
- Year
- 1991
- Tongue
- English
- Weight
- 738 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0085-2538
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## Background: The pathogenetic mechanisms by which individuals with chronic hepatitis b virus (hbv) infection develop membranous nephropathy (mn) are probably dependent on interactions between viral, host and environmental factors; some evidence suggests a genetic predisposition. hbvmn constitutes
Twelve of 32 patients lost HBeAg and DNA polymerase from their serum after completing antiviral therapy with interferon and/or adenine arabinoside. Three lost serum HBsAg as well. Loss of corresponding viral markers from hepatic tissue was also seen. There was improvement in symptoms, hepatic tests,
Ten patients with chronic type B hepatitis were treated with three courses of adenine arabinoside monosphosphate (Ara-AMP). The drug was given intramuscularly at a dosage of 10 mg/kg/day in ten-day courses during each of three sequential months. The patients were all men, aged 31-61 years, who were