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Treatment of Established Relapsing Experimental Autoimmune Encephalomyelitis with the Proteasome Inhibitor PS-5191

✍ Scribed by Carol L Vanderlugt; Sandra M Rahbe; Peter J Elliott; Mauro C Dal Canto; Stephen D Miller


Book ID
115621729
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
345 KB
Volume
14
Category
Article
ISSN
0896-8411

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Treatment of experimental autoimmune enc
✍ Merja Soilu-HΓ€nninen; Ruwan Epa; Kylie Shipham; Helmut Butzkueven; Tamara Bucci; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 721 KB

Upregulated expression of the low-affinity neurotrophin receptor (p75) in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) has recently been demonstrated. To investigate whether p75 plays a role in disease pathogenesis, we adopted a gene therapy approach, utili