Treatment of cystic fibrosis based on understanding CFTR
โ Scribed by A. E. Smith
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 652 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0141-8955
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Communicated by Claude Ferec Cystic fibrosis (CF) is mainly caused by mutations that interfere with the biosynthetic folding of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The aim of this study was to determine the mechanism of dysfunction of a disease-causi
In order to facilitate the screening for the less common mutations in the cystic fibrosis (CF) gene viz., the CF transmembrane conductance regulator gene (CFTR), marker haplotypes were determined for German non-CF (N) and CF chromosomes by polymerase chain reaction analysis of four polymorphisms ups
The cystic fibrosis transmembrane conductance regulator (CFTR) gene of 110 cystic fibrosis (CF) patients from the south-west of Germany was screened for 12 different mutations. This analysis resulted in an identification of 79% of all CF mutations and a complete genotype in 66% of the families. The
Cystic fibrosis (CF) is characterized by defective Cl -and enhanced Na + conductance, both due to malfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein in airway epithelial cells. In the present study we examined whether expression of CFTR mRNA (CFTR messenger ribonuc