Treatment of congenital afibrinogenemia with cryoprecipitate collected through a plasmapheresis program using dedicated donors
✍ Scribed by Hannis W. Thompson; Sondra Touris; Sheryl Giambartolomei; Rachelle Nuss
- Book ID
- 101259183
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 39 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0733-2459
No coin nor oath required. For personal study only.
✦ Synopsis
A child with afibrinogenemia was evaluated for prophylactic cryoprecipitate transfusion due to recurrent episodes of traumatic bleeding. The parents would only consider ongoing transfusion therapy if a limited donor program could be established. Automated plasmapheresis was performed on a regular basis on the patient's parents and a limited number of selected donors. Studies on the initial units collected demonstrated that a single 500 mL plasmapheresis yielded a mean of 606 mg fibrinogen in the cryoprecipitate, which was stored in two bags. A total of 166 U of cryoprecipitate from 84 individual plasmapheresis donations were transfused prophylactically every 2-3 weeks over a 16-month period. Compared to transfusions from random donors, the use of a limited number of apheresis donors resulted in a donor exposure reduction of 87%. Clinically, the patient has had minimal bleeding during this period.