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Treatment of classical Kaposi's sarcoma with intralesional injections of cidofovir: Report of a case

✍ Scribed by Simonart, Thierry; Noel, Jean-Christophe; De Dobbeleer, Gilbert; Parent, Dominique; Van Vooren, Jean-Paul; De Clercq, Erik; Snoeck, Robert

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 135 KB
Volume: 55
Category: Article
ISSN: 0146-6615
DOI: 10.1002/(sici)1096-9071(199807)55:3<215::aid-jmv6>3.0.co;2-4

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✦ Synopsis

The effect of intralesional injections of cidofovir, a nucleotide analog with potent in vitro activity against human herpesvirus 8 (HHV-8), was studied in vivo in an HIV-negative patient with classical Kaposi's sarcoma (KS). After five weekly injections of the drug, no clinical, histological, immunohistological, or virological changes could be detected in comparison with salineinjected lesions. These findings suggest that, once the KS tumor has developed, active viral replication is no longer involved in the pathogenesis of the disease. Alternative hypotheses are that HHV-8 replication in blood-borne cells may foster growth of spindle cells in the skin, or that blocking HHV-8 may not affect existing lesions but may prevent new lesions from developing.

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