P-glycoprotein influences the brain conc
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Joseph W. Polli; Todd M. Baughman; Joan E. Humphreys; Kelly H. Jordan; Angela L.
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Article
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2003
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John Wiley and Sons
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English
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Recent in vitro studies have suggested that P-glycoprotein (Pgp) and passive membrane permeability may influence the brain concentrations of non-sedating (second-generation) antihistamines. The purpose of this study was to determine the importance of Pgp-mediated efflux on the in vivo brain distribu