Treatment of chronic myeloid leukaemia lessons and challenges
β Scribed by John M. Goldman
- Publisher
- Carden Jennings Publishing
- Year
- 2002
- Tongue
- English
- Weight
- 668 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0925-5710
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## Abstract Chronic myeloid leukaemia (CML) is a clonal disorder of the haemopoietic stem cell arising as a consequence of the formation of the __bcrβabl__ oncogene. The particular molecular basis of this condition has enabled the development of therapies that selectively target diseased cells. The
Fourteen patients with poor-risk acute myelogenous leukaemia (AML) and five patients with accelerated phase/blast crisis chronic myeloid leukaemia (CML) were treated with 3 days of oral idarubicin (25 mg/m2/ day). No complete remissions or return to chronic phase CML were observed. A fall in the per
The low-cell-dose (LD) and the high-cell-dose (HD) transplant variants of the SA7 murine rnyeloid leukaemia cell line have different growth characteristics and clinical presentations. In addition, the low-cell-dose transplant subline (SA7LD) was more responsive than the high-cell-dose variant (SA7HD