Treatment of chronic discoid lupus erythematosus with thalidomide

✍ Scribed by J. Knop; R. Happle; G. Bonsmann; F. Vakilzadeh; E. Macher

• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 891 KB
• Volume: 271
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412543

✦ Synopsis

In an uncontrolled study the therapeutic effect of thalidomide on chronic discoid lupus erythematosus was investigated. In 24 patients (17 women, 7 men) with a history ranging from 0.5 -32 years and unresponsive to any previous therapeutic measures, complete or substantial regression of the disease was observed in 19 cases (80 %) after treatment with thalidomide. Side effects were somnolence, constipation, exanthema, oral dryness, and circulatory disturbances. None of these effects were serious.