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Treatment of an aggressive non-Hodgkin's lymphoma during pregnancy with MACOP-B chemotherapy

✍ Scribed by Nantel, Stephen ;Parboosingh, John ;Poon, Man-Chiu

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
249 KB
Volume
18
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Non‐Hodgkin's lymphoma occurring during pregnancy is a rare event. A young woman at 18 weeks gestation with twins presented with a B‐cell immunoblastic lymphoma. Combination chemotherapy with methotrexate, DO xorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP‐B) was instituted after limited staging. There was excellent response and the 12 weekly chemotherapy protocol was completed in 13 weeks. Twin male infants were born at 28 weeks gestation by cesarean section for premature labor. There was no evidence of any congenital malformations or hematologic suppressions. We believe this to be the first report of aggressive weekly chemotherapy during pregnancy; this approach to treatment in aggressive non‐Hodgkin's lymphoma is both efficacious and safe.

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