✦ LIBER ✦

Treatment of advanced adenocarcinomas of the exocrine pancreas and the gallbladder with 5-fluorouracil, high dose levofolinic acid and oral hydroxyurea on a weekly schedule: Results of a multicenter study of the Southern Italy Oncology Group (G.O.I.M.)

✍ Scribed by Vittorio Gebbia; Evaristo Majello; Antonio Testa; Giuseppe Pezzella; Serravezza Giuseppe; Francesco Giotta; Fernando Riccardi; Santo Fortunato; Giuseppe Colucci; Nicolò Gebbia

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 787 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960915)78:6<1300::aid-cncr19>3.0.co;2-4

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✦ Synopsis

BACKGROUND.

To date there is no established chemotherapeutic treatment for patients with unresectable locally advanced and/or metastatic carcinomas of the exocrine pancreas or the gallbladder. A multicenter Phase I1 trial has been performed by the Southern Italy Oncology Group with the aim of evaluating the clinical effectiveness and tolerability of weekly 5-fluorouracil (5-FU) in modulation with intravenous (i.v.) high dose levofolinic acid and oral hydroxyurea.