Treatment of adjuvant-induced arthritis by oral administration of mycobacterial Hsp65 during disease
β Scribed by Pieter M. Cobelens; Cobi J. Heijnen; Edward E. S. Nieuwenhuis; Peter P. G. Kramer; Ruurd Van Der Zee; Willem Van Eden; Annemieke Kavelaars
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 273 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0004-3591
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To assess the effect of orally administered type I1 collagen (CII) in antigen-induced arthritis (AIA). Methods. Arthritis was induced in Lewis rats by immunization with methylated bovine serum albumin (mBSA) in Freund's complete adjuvant, followed by an intraarticular injection of mBSA 2 weeks late
## Abstract ## Objective To prevent and treat experimental arthritis via nasal administration of an altered peptide ligand (APL) from the major arthritogenic epitope in adjuvantβinduced arthritis (AIA) and to explore the mechanisms involved. ## Methods Peptides were administered nasally before a